Nexavar is a cancer medication that interferes with the growth and spread of cancer cells in the body. Sorafenib stops or slows the growth of cancer cells (tumors). It also works by slowing the growth of new blood vessels within the tumor. Nexavar may also be used to treat a certain type of thyroid cancer (differentiated thyroid carcinoma).
Read the Patient Information Leaflet provided by your pharmacist before you start using sorafenib. Take this medication by mouth on an empty stomach (at least 1 hour before or 2 hours after a meal) as directed by your doctor, usually twice a day. Do not chew or crush the tablets. Swallow tablets whole with a full glass of water.
Nexavar can cause heart problems. Stop taking this medicine and call your doctor at once if you have chest pain and severe dizziness, fainting, sweating, or feeling short of breath. Nexavar can also cause severe bleeding. Call your doctor if you have blood in your urine or stools, abnormal vaginal bleeding, severe stomach pain, coughing up blood, or any bleeding that will not stop. Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. To lower the chance of getting cut, bruised or injured, use caution with sharp objects like safety razors and nail cutters, and avoid activities such as contact sports. Women who are pregnant must not take this medication as it can be absorbed through the skin and lungs and may harm an unborn baby.
Before taking sorafenib, tell your doctor or pharmacist if you are allergic to it. You should not use Nexavar if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane). Do not use Nexavar if you have kidney or liver problems other than cancer; lung cancer; a bleeding or blood clotting disorder such as hemophilia; high blood pressure (hypertension), heart disease, slow heartbeats, congestive heart failure, chest pain; a personal or family history of Long QT syndrome; a history of stroke or heart attack.
Possible side effect
The most common side effects are acne, dry skin, nausea, diarrhea, patchy hair loss/thinning, loss of appetite, dry mouth, hoarseness, or tiredness may occur. Notify your doctor if these effects persist or worsen. Serious side aeffects are bone/muscle pain, depression, easy bruising or bleeding, headache, tongue/mouth sores or pain, numbness/tingling of the hands/feet, shortness of breath, swollen hands/ankles/feet, signs of liver problems such as stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine. Check your blood pressure regularly as this medication may raise it. This medication can affect how your thyroid works. Tell your doctor right away if you have signs of an underactive thyroid such as weight gain, cold intolerance, slow heartbeat, constipation, or unusual tiredness or signs of an overactive thyroid such as mental/mood changes, heat intolerance, fast/pounding/irregular heartbeat or unusual weight loss. Contact your doctor right away if you notice skin problems (such as rash, blisters, redness, swelling, pain), especially on the palms of your hands or the soles of your feet.
The medications that may interact with Nexavar are dexamethasone, neomycin, St. John's wort, a blood thinner such as Warfarin, Coumadin, seizure medication such as carbamazepine, fosphenytoin, phenobarbital, phenytoin or tuberculosis medicine such as rifabutin, rifampin.
Take the missed dose as soon as you remember, but at least 2 hours since your last meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical help at once if someone has overdosed and has serious symptoms such as passing out or trouble breathing.
Store at room temperature away from moisture and heat.
The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment.